the Flu and others ORZ still remain the most mass infections. Viruses grippa, amazing various bodies and systems, on the average at 5 % of patients call tjazhelye hypertoxic forms.

Still there is high a disease of virus hepatitises (VG), kotorye can call not only sharp, but also chronic forms of illness with perehodom in a cirrhosis and gepatotselljuljarnuju kartsinomu with a lethal outcome. faktorom the toxic defeat of a liver first of all connected with parenteralnym by the use of drugs is disturbing. Consumption of drugs is accompanied porazheniem a liver, kidneys, immune system and other bodies and fabrics. Nedostatochnost the hepatic blood-groove, caused by an intoxication and soputstvujushchimi cardiovascular diseases, together with infringements mikrotsirkuljatsii and decrease in oxygen capacity lead gipoksii gepatotsitov.

Frequency of occurrence and weight of clinical displays of a syndrome poliorgannoj nedostatochnosti, arising as is functional-morphological result mnogokomponentnyh cascades postgipoksicheskih frustration of a fabric metabolism pri critical statuses, depend on nonspecific resistance of an organism, i first of all from resistance to gipoksii. In this connection in complex terapii such patients it is necessary to use preparations with antioksidantnoj, antigipoksantnoj activity, gepato - and nefroprotektornymi properties.

Researches of last years convince that endocellular activation kisloroda (education of active forms of oxygen-afk at an inflammation) can rassmatrivatsja, on the one hand, as a necessary stage biopower obmena, and with another - as the universal mechanism of damage of a cage.

For inaktivatsii negative influence AFK on cages and organism fabrics in poslednem there is a system antioksidantnoj protection (AOZ), consisting of nefermentnyh and fermental systems. Among components not fermental AOZ as nizkomolekuljarnye - ascorbic acid, uric acid, tocopherol, etc., so i high-molecular connections - fibers of plasma of blood.

last years in clinical practice are used biologically active veshchestva with a wide spectrum of pharmacological action - connections amber kisloty (YAK). Derivatives the YAK possess antioksidantnymi (joint-stock company) and tsitoprotektornymi svojstvami. As joint-stock company derivatives the YAK (suktsinat sodium, an amber elixir and dr.) Are applied at treatment and preventive maintenance of diseases cardiovascular and endokrinnoj systems, breath bodies at ekzogennyh intoxications.

It is shown, that ekzogennaja the YAK korrigiruet metabolic atsidoz and intensifitsiruet recycling of oxygen by fabrics that the YAK allows to characterise dejstvie derivatives at tsirkuljatornoj gipoksii as antigipoksicheskoe. In eksperimente on young rats the YAK increased resistibility of animals kombinirovannomu to infection with a virus and pnevmokokkom. The YAK (suktsinat sodium) is revealed positive terapevtichesky effect of preparations at their inclusion in the scheme lechenija lungs sick of a tuberculosis, a bronchial asthma.

Reamberin (RB) represents a solution for infusions on the basis of 2 %-s` rastvora salts of amber acid with N-metilgljukaminom and the balanced set mikroelementov - kalija, sodium and magnesium. Reamberin activates joint-stock company system fermentov and renders membranostabilizirujushchee action on cages head mozga, a myocardium, a liver and kidneys. Reamberin there has passed a complete course doklinicheskih issledovany which have shown absence toxic, mutagen and others pobochnyh influences on an organism. It is established experimentally, that a preparation obladaet expressed antigipoksicheskim, detoksitsirujushchim, antioksidantnym, kardio - i gepatoprotektornym by properties. Reamberin is issued in the form of 1,5 %-s` sterilnogo a solution in bottles on 200 and 400 ml.

Object of research were 96 sick of a flu and ORZ, complicated by a pneumonia. Vse patients in an age range from 18 till 60 years have been hospitalised in otdelenie respiratory virus infections of adults of scientific research institute of a flu on the basis of 23rd otdelenija city infectious hospital of With. P.Botkin. From them: 21 patients poluchal on 2 ml 7 %-s` solutions olifena intravenously kapelno three-five days; 37 - intravenously kapelno slowly - infusions 1,5 %-s` solutions reamberina in techenie three-five days; 20 - vitamin E (a-tocopherol) on one capsule (100 mg preparata) three times a day within eight-ten days; 18 - were only na basic therapy (BT - the clinical control).

by All patient it was spent standard clinical, radiological and laboratornoe inspection. Serologichesky research switched on statement on obshcheprinjatoj to a technique in dynamics RSK and RTGA with antigenes of viruses of a flu And and In, adenovirusnym, Rs-virus, mikoplazmennym and gerpeticheskimi entigenami. Diagnosticheskoj was considered quadruple and more serokonversija.

27 (SM) sick by a serous meningitis Are surveyed kliniko-laboratory, from them 16 received intravenous infusions on 300 ml 1,5 %-s` solutions reamberina / rtri-five days on end, and 11 persons have made the clinical control (BT).

Under supervision was 51 patients, suffering various forms VGV and VGS, v age of 18-55 years. Patients were distributed on three groups: I group - 24 bolnyh VG, receiving on 300-400 ml RB once a day during three-nine dnej successively (taking into account weight of illness) against basic therapy. II group - 12 bolnyh VG against only BT, and III group - 12 patients receiving RB five-nine dnej in complex therapies of heavy and heaviest forms VG at addicts (presence ekzo-endogennoj intoxications). All patients are surveyed biohimicheski, opredeljalsja level syvorotochnyh metalloproteidov in dynamics.

the Maintenance metalloproteidov (transferrina, laktoferrina, tseruloplazmina) in syvorotke blood of patients studied a method radial immunodiffuzii in agarovom gele on Manchini (1965). superoksiddismutazy (SOD) plasmas defined activity po to a method of decrease in speed of restoration nitrodark blue tetrazolija at presence NADN and fenazinmetasulfata and expressed in standard units for 1 minute, rasschitannyh on 1 ml of an investigated biological material (blood, plasma) or na 1 mg of fiber at job with plasma (whey).

defined by-products the SEX (malonovyj dialdegid - MDA) the so-called RTBK-test. The statistical analysis of the received results spent with the help otsenki criteria Stjudenta, and also a method of angular transformation of Fisher. Raschety were spent on microcomputer SM-1800.

Among sick of a flu complicated by a pneumonia, 84 % of patients have transferred zabolevanie in srednetjazheloj and only 16 % - in the heavy form (against application RB). Pathological process at patients was localised in the right lung in 64 %, in levom - in 23 %, bilateral defeats are noted in 13 %, and only at heavy bolnyh.

Preparation RB was appointed in the sharp period in first two-three days of hospitalisation. Vse patients transferred a preparation well. Kliniko-laboratory indicators of an estimation funktsii a liver and kidneys (definition syvorotochnyh ALat, AsaT, bilirubin, shchelochnoj fosfatazy, kreatinina, urea) were practically comparable with analogichnymi indicators in group of the clinical control and did not specify on fuktsionalnye infringement of the given bodies and systems.

Before application of preparation RB patients complained of a fever raised temperaturu 37,3-38,70С, weakness, a headache, osiplost voices, a cold, kashel dry and with mokrotoj, at a two the phenomena respiratory and vascular nedostatochnosti (heavy patients) were observed. After five days of course application RB bolshinstvo sick complaints did not show, state of health at luchshalos, syndromes intoksikatsii and kataralnyh the phenomena have passed. However at five patients were saved slabost, cough, subfebrilitit, the lowered appetite. Auskultativno at a part bolnyh dry rattles against rigid breath, at a three - individual vlazhnye rattles were listened. It is possible to tell, that application RB promoted reduction simptomov to an intoxication. However application of the given preparation authentically not umenshilo duration meningealnogo a syndrome, radiological izmenenija in lungs (in comparison with patients on BT).

Thus, good clinical shipping and harmlessness, and takzhe high therapeutic efficiency of a new domestic preparation reamberina is noted at treatment of a flu and ORZ, complicated by a pneumonia. It is revealed polozhitelnoe influence RB on restoration of ventilating ability of lungs and bronhialnoj passableness (shorter terms) in comparison with group klinicheskogo the control (р< 0,05).

In 1989 we to Russia and the CIS for studying of status AOS at patients grippom and ORZ have suggested to define for the first time the maintenance of the cores metalloproteidov in syvorotke blood: transferrina (TF), tseruloplazmina (CENTRAL PROCESSING UNIT), laktoferrina (LF) and SOD. The Same indicators have been used for an estimation of efficiency spent spetsificheskoj joint-stock company-therapy at treatment of a flu and other infections.

it is necessary to remind, that metalloproteidy the CENTRAL PROCESSING UNIT, TF and LF are fibers sharp fazy inflammations. The basic sign of fibers of this group - fast and considerable izmenenie concentration as a result of infringement of a homeostasis irrespective of the nature and mesta applications of the stimulus which has called it.

Reamberin and olifen (intravenously kapelno) rendered obvious korrigirujushchee vozdejstvie on the maintenance metalloproteidov, promoted more expressed stabilizatsii antioksidantnogo potential of whey of blood (in comparison with vitaminom E and BT), that was accompanied by improvement of the clinical status of patients.

by definition of levels of the cores metalloproteidov (TF, LF, the CENTRAL PROCESSING UNIT and SOD plasmas) researches For the first time have been carried out in whey and TSSZH 16 sick seroznymi (SM) and 11 patients with a purulent meningitis (H`M).

Infusions 1,5 %-s` reamberina spent in the sharp period of illness daily in techenie three-five days on end against complex therapy sick serous meningitami (SM). Essential decrease in indicators LF is noted in tserebrospinalnoj liquids (TSSZH) against reception RB while in control gruppe in blood whey value LF raised and maintenance TF decreased. Znachitelnym there was a CENTRAL PROCESSING UNIT decrease in TSSZH under influence reamberina, that specifies na antioksidantnuju activity of a preparation.

positive influence reamberina on clinical indicators Is revealed. So, on fone RB the fever proceeded 6,5 days, an intoxication 6,4, tsitoz was normalised na 38th day, kojko-day has made 46,5 days. Similar indicators in group on BT were - 8,9 days; 7,5 days; 46 and 56 days accordingly. Thus, vkljuchenie in complex therapy of SM reamberina it is represented expedient and soprovozhdaetsja distinct kliniko-laboratory effect.

In the given section the analysis of results of treatment reamberinom patients VG is presented.

All patient entered 300-400 ml of 1,5 % RB, the preparation was transferred well, allergicheskih reactions were not. Against therapy RB there passed symptoms intoksikatsii faster, a jaundice, pains in right podrebere and decreased the sizes of a liver. Polozhitelnaja clinical dynamics is noted at 50-82 % of patients.

earlier positive dynamics of biochemical indicators Is fixed.

Conclusions

1. Infusions 1,5 %-s` solutions reamberina within 3-12 days well perenosjatsja patients, collateral reactions were not observed. Reamberin it was combined with osnovnymi medicinal forms, possessed expressed dezintoksikatsionnym dejstviem. Reamberin promoted restoration of ventilating ability legkih and bronchial passableness, improved trophic processes in a myocardium.

2. Reamberin promoted increase antioksidantnogo whey potential krovi, to increase of nonspecific resistance of an organism sick of a flu and povysheniju to nonspecific resistance of an organism sick of a flu and ORZ, oslozhnennyh a pneumonia, nejroinfektsijami and virus hepatitises.

3. 1,5 %-s` solution reamberina is recommended as pathogenetic terapii at complex treatment sick of heavy forms of a flu and ORZ, oslozhnennymi a pneumonia, and also serous meningoentsefalitami, sharp and hronicheskimi forms of virus hepatitises (including at poliorgannyh defeats vsledstvie ekzoendogennogo a toxicosis).

Article is published in magazine Treating the Doctor